# A tibble: 8 x 7 # Groups: cluster [8] p_val avg_log2FC pct.1 pct.2 p_val_adj cluster gene 1 5.87e- 7 0.472 0.978 0.945 6.50e- 3 0 ZNF90 2 7.56e- 21 0.841 0.881 0.605 8.36e- 17 1 EGR1 3 5.89e- 24 0.851 1 0.893 6.52e- 20 2 QPCT 4 1.15e- 22 1.02 1 0.909 1.27e- 18 3 PMEL 5 3.00e- 21 0.617 0.359 0.051 3.32e- 17 4 IGFBP3 6 7.91e-112 2.30 0.868 0.013 8.76e-108 5 TYROBP 7 6.21e- 17 1.21 0.784 0.33 6.87e- 13 6 EMP1 8 1.72e- 97 2.69 0.773 0.005 1.91e- 93 7 IL32 $`0` GO_REGULATION_OF_FIBROBLAST_PROLIFERATION 5.021011e-08 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION 3.794958e-07 GO_BODY_FLUID_SECRETION 1.339489e-06 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE 2.742099e-06 GO_LIPID_PARTICLE 4.498715e-06 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS 5.938784e-06 GO_ORGAN_REGENERATION 6.046281e-06 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION 6.850291e-06 GO_DRUG_BINDING 7.911013e-06 GO_LEYDIG_CELL_DIFFERENTIATION 9.586940e-06 $`1` GO_DOPAMINE_BINDING 0.000000e+00 GO_REGULATION_OF_CELL_DEATH 6.609435e-10 GO_NEGATIVE_REGULATION_OF_CELL_DEATH 1.308803e-09 GO_TISSUE_DEVELOPMENT 2.451378e-09 GO_VASCULATURE_DEVELOPMENT 8.007353e-09 GO_EXTRACELLULAR_MATRIX 1.103687e-08 GO_BLOOD_VESSEL_MORPHOGENESIS 1.569380e-08 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY 3.275584e-08 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND 3.484356e-08 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT 7.115220e-08 $`2` GO_DOPAMINE_BINDING 0.000000e+00 GO_DEVELOPMENTAL_PIGMENTATION 3.352739e-13 GO_PIGMENTATION 3.494723e-10 GO_MELANIN_METABOLIC_PROCESS 3.387712e-09 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS 5.779952e-09 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 1.447213e-08 GO_MELANOCYTE_DIFFERENTIATION 2.160521e-08 GO_SENSORY_PERCEPTION 8.937313e-08 GO_PIGMENT_GRANULE 9.756427e-08 GO_PIGMENT_BIOSYNTHETIC_PROCESS 1.016971e-07 $`3` GO_DEVELOPMENTAL_PIGMENTATION 5.087229e-12 GO_PIGMENT_CELL_DIFFERENTIATION 4.432002e-10 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION 6.111849e-10 GO_MELANOCYTE_DIFFERENTIATION 1.234230e-09 GO_SENSORY_PERCEPTION 1.409755e-09 GO_PIGMENTATION 4.955694e-09 GO_NEUROLOGICAL_SYSTEM_PROCESS 2.367969e-08 GO_TISSUE_DEVELOPMENT 3.259033e-08 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION 4.094512e-08 GO_LOCOMOTION 1.294959e-07 $`4` GO_CHROMOSOME_CONDENSATION 4.905947e-09 GO_CELL_DIVISION 1.332850e-08 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT 4.093179e-08 GO_RESPONSE_TO_TYPE_I_INTERFERON 4.683131e-08 GO_CELL_CYCLE_PROCESS 1.384301e-07 GO_CELL_DEVELOPMENT 1.449518e-07 GO_MITOTIC_CELL_CYCLE 1.544753e-07 GO_RESPONSE_TO_INTERFERON_BETA 1.568915e-07 GO_DRUG_BINDING 2.365352e-07 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION 3.142129e-07 $`5` GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX 0.000000e+00 GO_LYSOZYME_ACTIVITY 0.000000e+00 GO_IMMUNE_SYSTEM_PROCESS 4.790931e-73 GO_IMMUNE_RESPONSE 1.211285e-61 GO_DEFENSE_RESPONSE 6.179176e-55 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 8.783094e-52 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 3.614967e-49 GO_REGULATION_OF_IMMUNE_RESPONSE 1.207959e-45 $`6` GO_REGULATION_OF_CELL_DEATH 1.583732e-09 GO_TISSUE_DEVELOPMENT 5.307936e-09 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS 7.762919e-09 GO_RESPONSE_TO_STARVATION 2.001507e-08 GO_CELL_DEATH 3.569363e-08 GO_REGULATION_OF_CELL_DIFFERENTIATION 8.797679e-08 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT 1.477277e-07 GO_CONNECTIVE_TISSUE_DEVELOPMENT 2.458754e-07 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS 2.507284e-07 GO_NEGATIVE_REGULATION_OF_CELL_DEATH 4.294116e-07 $`7` GO_IMMUNE_SYSTEM_PROCESS GO_IMMUNE_RESPONSE 8.944573e-49 2.620211e-41 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS GO_LEUKOCYTE_ACTIVATION 1.578926e-31 3.124282e-31 GO_LEUKOCYTE_CELL_CELL_ADHESION GO_CELL_ACTIVATION 2.809914e-30 1.353179e-29 GO_REGULATION_OF_IMMUNE_RESPONSE GO_LYMPHOCYTE_ACTIVATION 2.454324e-29 3.494804e-29 GO_CELL_CELL_ADHESION GO_DEFENSE_RESPONSE 4.034810e-27 4.470205e-26 # A tibble: 12 x 7 # Groups: cluster [12] p_val avg_log2FC pct.1 pct.2 p_val_adj cluster gene 1 1.54e- 6 0.388 0.409 0.092 1.71e- 2 Astrocyte EXOC3 2 3.96e- 9 0.318 0.273 0.017 4.38e- 5 Chondrocytes CXCL14 3 1.46e-46 2.74 0.773 0.037 1.61e-42 DC HLA-DQA1 4 1.26e- 5 0.842 0.765 0.342 1.39e- 1 Epithelial_cells BEX3 5 1.88e- 8 3.70 0.154 0.006 2.08e- 4 Fibroblasts COL1A1 6 1.49e-55 1.34 0.743 0.034 1.65e-51 Macrophage VSIG4 7 1.18e- 7 0.423 0.136 0.03 1.31e- 3 Neurons CENPF 8 6.31e-50 0.883 0.6 0.011 6.98e-46 Neutrophils CCRL2 9 4.83e-91 2.09 0.7 0.002 5.34e-87 NK_cell GZMA 10 6.93e- 5 0.368 0.154 0.014 7.67e- 1 Smooth_muscle_cells MANSC1 11 5.81e-85 1.62 0.571 0 6.43e-81 T_cells SPOCK2 12 5.25e-11 0.437 0.973 0.872 5.81e- 7 Tissue_stem_cells CCND1 $Astrocyte GO_MELANIN_METABOLIC_PROCESS 6.942171e-10 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS 1.186052e-09 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 2.977785e-09 GO_DEVELOPMENTAL_PIGMENTATION 7.625540e-09 GO_SECONDARY_METABOLIC_PROCESS 2.955634e-08 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS 2.385539e-07 GO_PIGMENTATION 6.573777e-07 GO_PIGMENT_BIOSYNTHETIC_PROCESS 6.881778e-07 GO_PIGMENT_METABOLIC_PROCESS 1.635748e-06 GO_PIGMENT_GRANULE 3.760813e-06 $Chondrocytes GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS 3.620682e-06 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY 9.886800e-06 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING 1.220443e-05 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS 3.070599e-05 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS 7.609268e-05 GO_GROWTH_FACTOR_BINDING 1.008869e-04 GO_LIPOXYGENASE_PATHWAY 1.265309e-04 GO_KERATAN_SULFATE_CATABOLIC_PROCESS 1.265309e-04 GO_GLIAL_CELL_FATE_COMMITMENT 1.265309e-04 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 1.265309e-04 $DC GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_LYSOZYME_ACTIVITY 0.000000e+00 GO_IMMUNE_SYSTEM_PROCESS 7.381650e-67 GO_IMMUNE_RESPONSE 5.118701e-58 GO_DEFENSE_RESPONSE 3.848586e-49 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 7.646307e-42 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 4.284434e-41 GO_REGULATION_OF_IMMUNE_RESPONSE 1.211152e-36 GO_EXTRACELLULAR_SPACE 1.011664e-31 $Epithelial_cells GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION 8.863286e-06 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE 2.053353e-05 GO_RIBONUCLEASE_P_ACTIVITY 2.053353e-05 GO_RESPONSE_TO_TYPE_I_INTERFERON 9.051861e-05 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION 9.538517e-05 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY 9.538517e-05 GO_SEQUESTERING_OF_METAL_ION 9.538517e-05 GO_SEGMENT_SPECIFICATION 9.538517e-05 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION 9.538517e-05 GO_RESPONSE_TO_MERCURY_ION 9.538517e-05 $Fibroblasts GO_EXTRACELLULAR_MATRIX_COMPONENT 3.637463e-05 GO_RESPONSE_TO_UV 3.912126e-05 GO_TBP_CLASS_PROTEIN_BINDING 3.987449e-05 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER 4.722596e-05 GO_REPLICATION_FORK 5.313312e-05 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION 8.397433e-05 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY 8.397433e-05 GO_BANDED_COLLAGEN_FIBRIL 8.397433e-05 GO_HEAD_MORPHOGENESIS 8.540535e-05 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION 1.243937e-04 $Macrophage GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_LYSOZYME_ACTIVITY 0.000000e+00 GO_IMMUNE_SYSTEM_PROCESS 9.433998e-58 GO_IMMUNE_RESPONSE 5.321980e-57 GO_DEFENSE_RESPONSE 6.406372e-51 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 4.967272e-41 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 1.422048e-40 GO_REGULATION_OF_IMMUNE_RESPONSE 3.318696e-37 GO_EXTRACELLULAR_SPACE 3.941013e-35 $Neurons GO_DOPAMINE_BINDING 0.000000e+00 GO_CATECHOLAMINE_BINDING 1.078032e-06 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 1.076085e-05 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY 1.076085e-05 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE 1.613155e-05 GO_KERATINIZATION 2.257056e-05 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS 2.257056e-05 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT 3.007595e-05 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY 3.007595e-05 GO_MICROTUBULE_DEPOLYMERIZATION 3.864578e-05 $Neutrophils GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY 0.000000e+00 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX 0.000000e+00 GO_LYSOZYME_ACTIVITY 0.000000e+00 GO_C_C_CHEMOKINE_RECEPTOR_ACTIVITY 0.000000e+00 GO_IMMUNE_SYSTEM_PROCESS 3.093175e-62 GO_IMMUNE_RESPONSE 1.018000e-61 GO_DEFENSE_RESPONSE 2.715518e-56 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 7.104038e-43 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 6.060128e-40 $NK_cell GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY GO_GLUTAMATE_RECEPTOR_ACTIVITY 0.000000e+00 0.000000e+00 GO_IMMUNE_SYSTEM_PROCESS GO_IMMUNE_RESPONSE 1.366111e-37 1.931286e-34 GO_DEFENSE_RESPONSE GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 5.670009e-25 2.854773e-24 GO_REGULATION_OF_IMMUNE_RESPONSE GO_CELL_ACTIVATION 2.339663e-23 6.288310e-23 GO_LEUKOCYTE_CELL_CELL_ADHESION GO_LEUKOCYTE_ACTIVATION 6.868299e-22 1.952213e-21 $Smooth_muscle_cells GO_AXON 3.583288e-07 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION 1.946983e-06 GO_NEURON_PROJECTION_DEVELOPMENT 3.300524e-06 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION 4.927801e-06 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION 5.975242e-06 GO_HSP90_PROTEIN_BINDING 9.974609e-06 GO_ANTEROGRADE_AXONAL_TRANSPORT 1.162048e-05 GO_NEURON_DEVELOPMENT 1.231520e-05 GO_NEURON_PROJECTION 1.265664e-05 GO_AXON_CYTOPLASM 2.533890e-05 $T_cells GO_IMMUNE_SYSTEM_PROCESS 3.777772e-37 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 3.497825e-29 GO_IMMUNE_RESPONSE 8.236676e-29 GO_LEUKOCYTE_ACTIVATION 1.452122e-27 GO_CELL_ACTIVATION 5.328024e-26 GO_REGULATION_OF_IMMUNE_RESPONSE 7.847702e-26 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 3.581597e-25 GO_LYMPHOCYTE_ACTIVATION 9.653512e-25 GO_LEUKOCYTE_CELL_CELL_ADHESION 2.299923e-23 GO_REGULATION_OF_CELL_ACTIVATION 7.289431e-22 $Tissue_stem_cells GO_NEGATIVE_REGULATION_OF_CELL_DEATH 1.955517e-09 GO_REGULATION_OF_CELL_DEATH 3.808824e-09 GO_TISSUE_DEVELOPMENT 8.012731e-08 GO_HEPARIN_BINDING 1.088166e-07 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION 1.600222e-07 GO_REGULATION_OF_CELL_PROLIFERATION 2.553836e-07 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION 7.610824e-07 GO_GLYCOSAMINOGLYCAN_BINDING 8.772312e-07 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT 8.857652e-07 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 1.806850e-06