# A tibble: 8 x 7 # Groups: cluster [8] p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene 1 8.50e-79 0.325 1 1 1.16e-74 0 APOE 2 3.33e-53 0.296 1 1 4.54e-49 1 ALB 3 8.11e-93 1.07 0.845 0.232 1.10e-88 2 MT1G 4 1.79e-80 0.700 1 1 2.44e-76 3 ALB 5 5.54e-93 2.11 1 0.77 7.55e-89 4 IGHG1 6 6.00e-34 1.20 0.881 0.441 8.17e-30 5 REG3A 7 3.49e-32 0.695 0.753 0.249 4.76e-28 6 ADIRF 8 6.20e-45 0.431 0.543 0.035 8.44e-41 7 MS4A1 $`0` GO_BLOOD_MICROPARTICLE 5.482004e-11 GO_VESICLE_LUMEN 7.483274e-10 GO_VASODILATION 6.469878e-09 GO_EXTRACELLULAR_SPACE 1.243612e-08 GO_MACROMOLECULAR_COMPLEX_REMODELING 1.262309e-08 GO_SECRETORY_GRANULE_LUMEN 1.732405e-08 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION 3.871975e-08 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION 7.515988e-08 GO_REGULATION_OF_RESPONSE_TO_WOUNDING 8.679966e-08 GO_PLATELET_DEGRANULATION 1.065924e-07 $`1` GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM 1.595222e-08 GO_CELL_KILLING 5.940936e-07 GO_LYASE_ACTIVITY 6.856259e-07 GO_PYRIDOXAL_PHOSPHATE_BINDING 9.423762e-07 GO_ORGANIC_ACID_BINDING 9.835442e-07 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS 1.031821e-06 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP 1.811942e-06 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS 2.422991e-06 GO_PYRUVATE_METABOLIC_PROCESS 2.737242e-06 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 3.019017e-06 $`2` GO_CELLULAR_RESPONSE_TO_ZINC_ION 5.161075e-13 GO_RESPONSE_TO_ZINC_ION 6.311562e-10 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION 9.038134e-10 GO_RESPONSE_TO_CADMIUM_ION 7.326089e-08 GO_NEGATIVE_REGULATION_OF_COAGULATION 1.255067e-07 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE 1.278821e-07 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE 1.278821e-07 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING 3.329194e-07 GO_REGULATION_OF_GROWTH 4.036227e-07 GO_VASODILATION 1.075225e-06 $`3` GO_EXTRACELLULAR_SPACE 8.707783e-14 GO_VESICLE_LUMEN 6.151428e-13 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION 8.382190e-13 GO_PLATELET_ALPHA_GRANULE_LUMEN 1.007735e-12 GO_PLATELET_ALPHA_GRANULE 8.363144e-12 GO_SECRETORY_GRANULE_LUMEN 9.362819e-12 GO_ANTIMICROBIAL_HUMORAL_RESPONSE 9.893321e-11 GO_PLATELET_DEGRANULATION 1.237750e-10 GO_BLOOD_MICROPARTICLE 4.085134e-10 GO_DEFENSE_RESPONSE_TO_BACTERIUM 4.641154e-10 $`4` GO_ANTIGEN_BINDING 3.817412e-32 GO_DEFENSE_RESPONSE 4.873446e-23 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN 6.040644e-23 GO_REGULATION_OF_IMMUNE_RESPONSE 8.386861e-23 GO_IMMUNE_RESPONSE 8.970459e-23 GO_INNATE_IMMUNE_RESPONSE 1.828001e-22 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 3.341772e-22 GO_B_CELL_MEDIATED_IMMUNITY 4.109380e-22 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION 2.436427e-21 GO_HUMORAL_IMMUNE_RESPONSE 2.743868e-21 $`5` GO_EXTRACELLULAR_SPACE 3.669219e-13 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE 1.213333e-12 GO_PROTEIN_LIPID_COMPLEX 2.837328e-11 GO_OXIDOREDUCTASE_ACTIVITY 3.011288e-11 GO_OXIDATION_REDUCTION_PROCESS 1.103485e-10 GO_ORGANIC_ACID_METABOLIC_PROCESS 1.851445e-09 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS 3.924692e-09 GO_SMALL_MOLECULE_METABOLIC_PROCESS 5.487666e-09 GO_MACROMOLECULAR_COMPLEX_REMODELING 7.691841e-09 GO_ORGANIC_ACID_CATABOLIC_PROCESS 8.938948e-09 $`6` GO_EXTRACELLULAR_SPACE 9.003651e-23 GO_DEFENSE_RESPONSE 2.057228e-22 GO_MHC_PROTEIN_COMPLEX 4.809356e-21 GO_IMMUNE_RESPONSE 1.790651e-18 GO_CYTOPLASMIC_VESICLE_PART 8.025314e-18 GO_LUMENAL_SIDE_OF_MEMBRANE 1.119812e-17 GO_ER_TO_GOLGI_TRANSPORT_VESICLE 1.233144e-17 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE 4.047085e-17 GO_ANTIGEN_BINDING 2.778037e-16 GO_SIDE_OF_MEMBRANE 4.128756e-16 $`7` GO_MHC_PROTEIN_COMPLEX 1.304180e-18 GO_RESPONSE_TO_CYTOKINE 5.052838e-17 GO_ANTIGEN_BINDING 9.347150e-17 GO_SIDE_OF_MEMBRANE 1.416878e-16 GO_CELL_SURFACE 1.284711e-15 GO_LUMENAL_SIDE_OF_MEMBRANE 1.722770e-15 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION 3.383771e-15 GO_EXTRACELLULAR_MATRIX 3.907238e-15 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 4.643772e-15 GO_REGULATION_OF_CELL_ACTIVATION 5.361552e-15 # A tibble: 5 x 7 # Groups: cluster [5] p_val avg_logFC pct.1 pct.2 p_val_adj cluster gene 1 9.81e-70 0.462 1 0.963 1.34e-65 m_REG3A GLUL 2 1.01e-13 0.265 0.947 0.873 1.38e- 9 m_ADIRF DCXR 3 1.91e-80 0.997 0.966 0.577 2.60e-76 m_IGKC TMSB10 4 2.52e-60 0.468 1 1 3.43e-56 m_HAMP ALB 5 5.30e- 9 0.366 0.709 0.437 7.22e- 5 m_PCK1 FTCD $m_REG3A GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE 4.085134e-10 GO_BLOOD_MICROPARTICLE 4.085134e-10 GO_CELLULAR_RESPONSE_TO_ZINC_ION 2.026585e-09 GO_VESICLE_LUMEN 3.971565e-09 GO_RESPONSE_TO_ZINC_ION 4.791707e-09 GO_VASODILATION 1.864553e-08 GO_MACROMOLECULAR_COMPLEX_REMODELING 3.634639e-08 GO_SECRETORY_GRANULE_LUMEN 6.679661e-08 GO_CELLULAR_CHEMICAL_HOMEOSTASIS 7.186524e-08 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION 8.396565e-08 $m_ADIRF GO_CARBOHYDRATE_CATABOLIC_PROCESS GO_CELLULAR_CATABOLIC_PROCESS 0 0 GO_PROTEIN_HOMOTETRAMERIZATION GO_NADP_METABOLIC_PROCESS 0 0 GO_COFACTOR_METABOLIC_PROCESS GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS 0 0 GO_SMALL_MOLECULE_METABOLIC_PROCESS GO_MONOSACCHARIDE_CATABOLIC_PROCESS 0 0 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS 0 0 $m_IGKC GO_ANTIGEN_BINDING 7.495477e-33 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 1.115919e-25 GO_INNATE_IMMUNE_RESPONSE 5.556469e-25 GO_IMMUNE_RESPONSE 8.928010e-25 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN 9.140683e-25 GO_REGULATION_OF_IMMUNE_RESPONSE 5.960591e-24 GO_SIDE_OF_MEMBRANE 6.788476e-24 GO_HUMORAL_IMMUNE_RESPONSE 8.810914e-24 GO_B_CELL_MEDIATED_IMMUNITY 2.140673e-23 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 6.527943e-23 $m_HAMP GO_VESICLE_LUMEN GO_PLATELET_ALPHA_GRANULE_LUMEN 1.353396e-17 2.541196e-15 GO_EXTRACELLULAR_SPACE GO_PLATELET_ALPHA_GRANULE 1.076225e-14 2.940376e-14 GO_SECRETORY_GRANULE_LUMEN GO_SECRETORY_GRANULE 3.350204e-14 1.872552e-13 GO_PLATELET_DEGRANULATION GO_BLOOD_MICROPARTICLE 6.600199e-13 2.616971e-12 GO_SECRETORY_VESICLE GO_CYTOPLASMIC_VESICLE_PART 2.889441e-12 6.764436e-12 $m_PCK1 GO_LYASE_ACTIVITY 3.455324e-07 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS 3.963623e-07 GO_ORGANIC_ACID_BINDING 4.960545e-07 GO_MONOSACCHARIDE_METABOLIC_PROCESS 5.368021e-07 GO_CELLULAR_CATABOLIC_PROCESS 1.283331e-06 GO_STEROID_METABOLIC_PROCESS 1.298358e-06 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS 1.518216e-06 GO_PYRUVATE_METABOLIC_PROCESS 1.715311e-06 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS 4.753321e-06 GO_SMALL_MOLECULE_CATABOLIC_PROCESS 5.203499e-06 $m_TTPAL GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION 0 GO_CARDIAC_CHAMBER_DEVELOPMENT 0 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY 0 GO_CIRCADIAN_RHYTHM 0 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING 0 GO_SPINAL_CORD_DEVELOPMENT 0 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 0 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS 0 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY 0 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION 0 $m_REG3A [1] "REG3A" "MT1G" "GLUL" "MT1X" "DCXR" "MT2A" [7] "AZGP1" "SPARCL1" "SCD" "AGT" "KNG1" "G6PC" [13] "HSD11B1" "PLG" "MME" "AHSG" "APOE" "CTH" [19] "AADAC" "TF" "FASN" "HGD" "ADH1B" "AQP9" [25] "SLC38A3" "APOC3" "CPB2" "SERPIND1" "LINC00844" "RHBG" [31] "XPNPEP2" "SIAH2" "CHAC1" "SEC14L2" "PAH" "SHISA4" [37] "NOTUM" "ALDH3A2" "CYP2E1" "METTL7A" "SLC2A4RG" "ALDOB" [43] "CYP8B1" "SPDEF" "PDK4" "SLC30A10" "C1QTNF3" "HPD" [49] "GGH" "ACAA1" "SEPT4" "SDC2" "SLC22A3" "MT1E" [55] "HEPACAM" "ZFAND5" "BEX3" "ALDH6A1" "CYP2C8" "GLUD1" [61] "SPP1" "GATM" "TAT" "SLC2A2" "CPS1" "GPRC5C" [67] "ATP1B1" "EPHX1" "AKR1C2" "SLC16A11" "RXRG" $m_LCN2 [1] "LCN2" "SREBF1" "ZDHHC8" "DDAH2" "AGPAT1" [6] "GLI4" "IFRD2" "SMPDL3A" "QSOX2" "FKTN" [11] "SAA2" "ARL4A" "TGIF1" "SPRED2" "RNLS" [16] "LYRM4" "UGGT1" "AMPD2" "BIN3" "FOXO3" [21] "DNAJC4" "CRELD1" "SLC7A6" "AC098850.3" "TAB3" [26] "HABP4" "CDC42BPB" "GSDMB" "JOSD1" "MED23" [31] "EXOC5" "WBP1L" "WIPF2" $m_ADIRF [1] "ADIRF" "APOC1" "UGT2B4" "HPR" "DENND5B" "AK4" $m_IGKC [1] "IGKC" "IGHG1" "IGHG3" "IGLC3" "IGHGP" "TMSB10" [7] "CD74" "IGLC2" "IGHG4" "TMSB4X" "IGFBP7" "CCL21" [13] "TIMP1" "HLA-DRB1" "HLA-DRA" "CCL19" "S100A6" "PTGDS" [19] "TAGLN" "IGHM" "CD52" "CXCR4" "SH3BGRL3" "CYBA" [25] "AEBP1" "IGLL5" "HLA-DPB1" "HLA-DPA1" "TRBC2" "C1QB" [31] "LAPTM5" "HLA-B" "COL1A1" "GGT5" "JCHAIN" "C1QA" [37] "VIM" "IL7R" "TXNIP" "SSR4" "COL6A2" "CYR61" [43] "HLA-DQB1" "CORO1A" "LIMD2" "MZB1" "LGALS1" "SRGN" [49] "CTGF" "JUNB" "COL1A2" "INMT" "CST3" "ARHGAP45" [55] "DCN" "B2M" "PTPRC" "HLA-A" "CD53" "IGHA1" [61] "EMILIN1" $m_HAMP [1] "HAMP" "FABP1" "SPINK1" "ALB" "HP" "ORM1" [7] "A2M" "FGB" "SERPINA1" "FGG" "FGA" "SAA1" [13] "LBP" "NNMT" "ACSL4" "FGL1" "CYP2A6" "ANG" [19] "CHI3L1" "IL32" "DEFB1" "ORM2" $m_PCK1 [1] "PCK1" "SDS" "FTCD" "HIP1R" "CYP3A4" [6] "CYP4A11" "AKR1B10" "ARV1" "AD000090.1" "UGT2B7" [11] "KDM7A" $m_TTPAL [1] "TTPAL" "VKORC1L1" "F7" "FAM160A2" "AVL9" [6] "NEK4" "MIA2" "NFIC" "FBLN7" "ORAI3" [11] "STARD10" "FMO4" "PIGU" "ZBTB38" "NEAT1" [16] "SLC23A2" "ZNF652" "TMED5" "DENND4B" "PLXNB2" [21] "FAM174A" "DLGAP1-AS1" "SLC25A23" "SCAP" "UBN2" [26] "HMGN5" "PNPLA7" "GDF7" "C9orf72" "CRKL" [31] "ACSF2" "ERRFI1" "FPGT" "BICRA" "APOA5" [36] "CCDC130" "ARSD" "TSPAN13" "MTTP" "HNF1A" [41] "ZKSCAN1" "SART1" "RANBP6" "MLXIPL" "KHK" [46] "ZNF862" "CDC42BPA" "FYB2" "FGFR4" "VPS13A" [51] "RNF152" "DCAF5" "ZNRF3" m_REG3A [1,] "GO_RESPONSE_TO_ZINC_ION" [2,] "GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE" [3,] "GO_ORGANIC_ACID_METABOLIC_PROCESS" [4,] "GO_SMALL_MOLECULE_METABOLIC_PROCESS" [5,] "GO_SMALL_MOLECULE_CATABOLIC_PROCESS" [6,] "GO_ORGANIC_ACID_CATABOLIC_PROCESS" [7,] "GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS" [8,] "GO_OXIDATION_REDUCTION_PROCESS" [9,] "GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS" [10,] "GO_CELLULAR_RESPONSE_TO_ZINC_ION" m_LCN2 [1,] "GO_REGULATION_OF_PROTEIN_DEACETYLATION" [2,] "GO_CITRULLINE_METABOLIC_PROCESS" [3,] "GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES" [4,] "GO_REGULATION_OF_MITOPHAGY" [5,] "GO_RESPONSE_TO_SALT" [6,] "GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION" [7,] "GO_CO_SMAD_BINDING" [8,] "GO_REGULATION_OF_PROTEIN_GLYCOSYLATION" [9,] "GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS" [10,] "GO_OOCYTE_MATURATION" m_ADIRF [1,] "GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE" [2,] "GO_PROTEIN_LIPID_COMPLEX" [3,] "GO_MONOCARBOXYLIC_ACID_BINDING" [4,] "GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY" [5,] "GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT" [6,] "GO_PHOSPHOLIPID_EFFLUX" [7,] "GO_CHYLOMICRON" [8,] "GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY" [9,] "GO_LIPASE_INHIBITOR_ACTIVITY" [10,] "GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS" m_IGKC [1,] "GO_ANTIGEN_BINDING" [2,] "GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION" [3,] "GO_REGULATION_OF_CELL_ACTIVATION" [4,] "GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN" [5,] "GO_SIDE_OF_MEMBRANE" [6,] "GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS" [7,] "GO_B_CELL_MEDIATED_IMMUNITY" [8,] "GO_INNATE_IMMUNE_RESPONSE" [9,] "GO_LYMPHOCYTE_MEDIATED_IMMUNITY" [10,] "GO_HUMORAL_IMMUNE_RESPONSE" m_HAMP [1,] "GO_EXTRACELLULAR_SPACE" [2,] "GO_VESICLE_LUMEN" [3,] "GO_PLATELET_ALPHA_GRANULE_LUMEN" [4,] "GO_ACUTE_INFLAMMATORY_RESPONSE" [5,] "GO_PLATELET_ALPHA_GRANULE" [6,] "GO_ACUTE_PHASE_RESPONSE" [7,] "GO_SECRETORY_GRANULE_LUMEN" [8,] "GO_PLATELET_DEGRANULATION" [9,] "GO_BLOOD_MICROPARTICLE" [10,] "GO_DEFENSE_RESPONSE" m_PCK1 [1,] "GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS" [2,] "GO_SMALL_MOLECULE_METABOLIC_PROCESS" [3,] "GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS" [4,] "GO_STEROID_METABOLIC_PROCESS" [5,] "GO_ORGANIC_ACID_METABOLIC_PROCESS" [6,] "GO_POLYOL_BIOSYNTHETIC_PROCESS" [7,] "GO_ALCOHOL_BIOSYNTHETIC_PROCESS" [8,] "GO_ANDROGEN_METABOLIC_PROCESS" [9,] "GO_LIPID_METABOLIC_PROCESS" [10,] "GO_OXYGEN_BINDING" m_TTPAL [1,] "GO_ACYLGLYCEROL_HOMEOSTASIS" [2,] "GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS" [3,] "GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION" [4,] "GO_PROTEIN_CARBOXYLATION" [5,] "GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS" [6,] "GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST" [7,] "GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS" [8,] "GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY" [9,] "GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION" [10,] "GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION"